Tofacitinib CAS:477600-75-2 Mea Hana Mea Hoʻolako Kiʻi Hōʻike ʻia

Tofacitinib CAS:477600-75-2 Mea Hoʻolako Mea Hana

ʻO Tofacitinib ka mua liʻiliʻi liʻiliʻi kinase inhibitor i ʻae ʻia no ka mālama ʻana iā RA.ʻO Tofacitinib ka mea paʻa o nā subtypes ʻehā o Janus kinase (JAK): JAK1, JAK2, JAK3, a me Tyk2. Tofacitinib hana ma ke kāohi ʻana i ka phosphorylation a me ka hoʻoulu ʻana o nā transducers hōʻailona a me nā mea hoʻouluulu o ka transcription (STATs), a laila ke kāohi nei i ka hana ʻana o nā mediators inflammatory. i loko o ke kino hui.

Kauoha a Noi Manao

Huahana Huahana

Hoʻohana a me ka hopena

He lāʻau lapaʻau ʻo Tofacitinib no ka mālama ʻana i ka rheumatoid arthritis (RA), psoriasis, ka maʻi ʻeha o ka ʻōpū, a me nā maʻi immunological ʻē aʻe, a no ka pale ʻana i ka hōʻole ʻana o ke kino.He mea pale ia o ka enzyme Janus kinase 3 (JAK3), 'o ia ho'i, e ho'opilikia i ke ala hō'ailona JAK-STAT e ho'ouna ana i ka 'ike ma waho o ke kelepona i loko o ka nucleus cell, e ho'ohuli ana i ka palapala DNA.I kēia mau lā, ua hōʻike ʻia i loko o kahi kumu hoʻohālike murine o ka arthritis i hoʻokumu ʻia, tofacitinib wikiwiki i hoʻomaikaʻi ʻia i ka maʻi ma o ke kāohi ʻana i ka hana ʻana o nā mea hoʻopuʻi a me ka hoʻopaʻa ʻana i nā genes hilinaʻi STAT1 i loko o nā kiko hui. nā ala, e hōʻike ana e hiki i ka tofacitinib ke hoʻohana i ka pōmaikaʻi therapeutic ma o nā alahele ʻaʻole wale i ka pale ʻana o JAK3.

Laʻana Huahana

Hoʻopili huahana:

ʻIke hou aku:

Huina	C16H20N6O
Hoʻāʻo	99%
Ka nana aku	ʻO ka pauka keʻokeʻo
CAS No.	477600-75-2
Hoʻopili	25KG
Ola Pahu	2 makahiki
Waihona	E mālama ma kahi maloʻo a maloʻo
Palapala hōʻoia	ISO.