β-Nicotinamide Mononucleotide CAS:1094-61-7

Hoʻohana ʻia ka β-Nicotinamide mononucleotide (NMN) e aʻo i nā kumu paʻa i loko o nā aptamers RNA a me nā kaʻina hana hoʻoulu ribozyme e pili ana i ka β-nicotinamide mononucleotide (β-NMN) - nā ʻāpana RNA i hoʻoikaika ʻia.ʻO NMN kahi nucleotide i loaʻa mai ka ribose a me ka nicotinamide.ʻO ka Niacinamide (nicotinamide,) he mea ia o ka huaʻa B3, ʻike ʻia hoʻi ʻo niacin.) Ma ke ʻano he biochemical precursor o NAD +, pono paha ia i ka pale ʻana i ka pellagra.
ʻO ka β-Nicotinamide mononucleotide kahi mea waena i ka biosynthesis o nicotinamide adenine dinucleotide (NAD+).Hoʻopili ʻo Nicotinamide phosphoribosyltransferase (Nampt) i ka condensation o nicotinamide me 5-phosphoribosyl-1-pyrophosphate e hoʻohua i ka β-NMN, a laila hoʻololi ʻia i NAD + e β-NMN adenyltransferase. Ma 50-100 μM, ua hoʻohana ʻia ka β-NMN. NAD biosynthesis a me ka glucose-stimulated insulin secretion in a Nampt +/- mouse model of metabolic disease, e hōʻike ana i kahi kuleana no Nampt i ka hana β cell.