β-Nicotinamide Mononucleotide CAS:1094-61-7

Hoʻohana ʻia ka β-Nicotinamide mononucleotide (NMN) e aʻo i nā motif hoʻopaʻa i loko o nā RNA aptamers a me nā kaʻina hana hoʻāla ribozyme e pili ana i nā ʻāpana RNA i hoʻāla ʻia e β-nicotinamide mononucleotide (β-NMN). ʻO NMN kahi nucleotide i loaʻa mai ka ribose a me ka nicotinamide. ʻO Niacinamide (nicotinamide,) kahi derivative o ka huaora B3, i ʻike ʻia hoʻi ʻo niacin.) Ma ke ʻano he biochemical precursor o NAD+, he mea pono paha ia i ka pale ʻana i ka pellagra.
ʻO ka β-Nicotinamide mononucleotide kahi waena i ka biosynthesis o ka nicotinamide adenine dinucleotide (NAD+). Hoʻoulu ka Nicotinamide phosphoribosyltransferase (Nampt) i ka condensation o ka nicotinamide me 5-phosphoribosyl-1-pyrophosphate e hana i ka β-NMN, kahi i hoʻololi ʻia i NAD+ e ka β-NMN adenyltransferase. Ma 50-100 μM, ua hoʻohana ʻia ka β-NMN e hoʻonui i ka biosynthesis NAD a me ka glucose-stimulated insulin secretion i loko o kahi kumu hoʻohālike ʻiole Nampt+/- o ka maʻi metabolic, e hōʻike ana i kahi kuleana no Nampt i ka hana β cell.