2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE CAS:407-38-5

ʻO 2,2,2-Trifluoroethyl trifluoroacetate (TFETA) kahi hui like ʻole me nā waiwai kemika ʻokoʻa e hāʻawi i kona pono ākea i nā noi ʻoihana like ʻole. Nā Waiwai Hōʻike ʻia ʻo TFETA e kona ʻano molekala, e hōʻike ana i kahi hui trifluoroethyl (-CF3CH2-) i hoʻopili ʻia i kahi ester trifluoroacetate (-OC(O)CF3). ʻO kēia hui pū ʻana e hopena i kahi wai maopopo, kala ʻole me kahi kiko paila kiʻekiʻe, ma kahi o 145°C, a me ka solubility maikaʻi loa i nā mea hoʻoheheʻe organik. Hōʻike ka hui i ka reactivity haʻahaʻa ma muli o ke ʻano electron-withdrawal o nā ʻātoma fluorine, e hāʻawi ana i ka paʻa kemika paʻa ma lalo o nā kūlana like ʻole. ʻO nā waiwai o TFETA e kūpono ia no nā noi e koi ana i ka inertness, e like me ka synthesis o nā intermediates paʻa a me nā uhi pale. Hoʻohana Organic Synthesis: Hana ʻo TFETA ma ke ʻano he intermediate koʻikoʻi i ka synthesis organik, kahi e komo ai i nā hopena e hoʻolauna i nā hana fluorinated i loko o nā molekala paʻakikī. He mea waiwai nui kēia hiki i ka kemika lāʻau lapaʻau no ka hana ʻana i nā lāʻau fluorinated a me ka hana ʻana i nā kemika kūikawā kahi e makemake ʻia ai ka paʻa a me ke kū'ē kemika. ʻEpekema Mea Hana: ʻO ke kūpaʻa kemika a me ka solubility o TFETA e lilo ia i ʻāpana kūpono i ka hoʻokumu ʻana o nā uhi a me nā mea me nā koi hana kikoʻī. Hoʻohana ʻia ia e hoʻonui i ke kūpaʻa a me nā waiwai pale o nā ʻili e kūʻē i ka hōʻino ʻana o ke kaiapuni a me ka hoʻouka kemika, e hāʻawi ana i ka lōʻihi o nā mea i nā noi mai nā uhi kaʻa a hiki i nā ʻāpana uila. Nā noi lāʻau lapaʻau: Hoʻonui ka hana a TFETA i ka synthesis organik i nā noi lāʻau lapaʻau, kahi e hiki ai i kona ʻano fluorinated ke hoʻololi i ka hana olaola a me nā waiwai pharmacokinetic o nā molekala lāʻau. ʻO kēia ka mea e lilo ai i mea hana waiwai i ka ʻike lāʻau a me nā kaʻina hana hoʻomohala e pili ana i ka hoʻomaikaʻi ʻana i ka pono therapeutic a me ka bioavailability. Synthesis TFETA synthesized ma o ka esterification o ka trifluoroacetic acid (CF3COOH) me 2,2,2-trifluoroethanol (CF3CH2OH) ma lalo o nā kūlana acidic. Hoʻopuka ka hopena i ka TFETA me ka wai ma ke ʻano he byproduct, hiki ke hoʻomaʻemaʻe ʻia ma o ka distillation a i ʻole ka solvent extraction e hoʻokō i ka maʻemaʻe kiʻekiʻe kūpono no nā noi ʻoihana. ʻO ka synthesis pololei a me ka lawelawe ʻana o TFETA e hāʻawi i kona kumukūʻai kūpono a me ka hoʻohana ākea ma nā ʻāpana like ʻole e koi ana i nā hui fluorinated. I ka hōʻuluʻulu manaʻo, he hui like ʻole ka 2,2,2-trifluoroethyl trifluoroacetate e pono ai i ka synthesis organik, ka ʻepekema mea, a me ka kemika lāʻau lapaʻau. ʻO kona mau waiwai kemika kū hoʻokahi e hiki ai ke hoʻomohala i nā mea holomua a me nā lāʻau lapaʻau me ka hoʻonui ʻia o ke kūpaʻa a me nā ʻano hana, e hōʻike ana i kona koʻikoʻi i nā noi ʻoihana hou.