(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride CAS:188416-35-5

Hoʻohana ʻia ka (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride i ke kemika lāʻau lapaʻau no kāna mau hana pharmacological hiki a me nā noi therapeutic. Hiki i kēia hui ke hōʻike i nā waiwai anti-proliferative, anti-inflammatory, a i ʻole enzyme inhibitory i pono i ka mālama ʻana i nā maʻi like ʻole, me ke kanesa, ka mumū, a me nā kūlana maʻi. I ka ʻike ʻana i ka lāʻau lapaʻau, hoʻohana nā mea noiʻi i ka (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride e hoʻolālā a synthesize i nā hui hou me ka ikaika i hoʻonui ʻia, selectivity, a me ka bioavailability. Ma ka hoʻololi ʻana i kona ʻano kemika a me ka ʻimi ʻana i nā pilina hana-ʻano, makemake nā kānaka ʻepekema e hoʻomohala i nā mea therapeutic hou e kuhikuhi ana i nā ala molekala kikoʻī a me nā pahuhopu biological i pili i nā maʻi. Eia kekahi, lawelawe kēia hui ma ke ʻano he scaffold molekala no ka synthesis o nā moho lāʻau lapaʻau hiki ke loaʻa me nā ʻano pharmacokinetic i hoʻonui ʻia a me ka hoʻomaikaʻi ʻana i ka pono therapeutic. ʻO kāna mau pilina me nā pahuhopu cellular, nā ala hōʻailona, ​​​​a me nā biomarkers maʻi e hāʻawi i ka ʻike i kona mau hopena olaola a me nā ʻano hana, e alakaʻi ana i ka hoʻomohala ʻana o nā lāʻau lapaʻau i kuhikuhi ʻia a me nā lāʻau lapaʻau pilikino no nā poʻe maʻi me nā pono olakino i hoʻokō ʻole ʻia. Eia kekahi, hiki ke hoʻohana ʻia ka (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride i nā haʻawina preclinical e loiloi i kona palekana, pono, a me nā waiwai pharmacological ma mua o ka neʻe ʻana i nā hoʻokolohua lapaʻau. Ua loiloi ʻia kona bioactivity, nā hopena pharmacodynamic, a me nā hopena ʻaoʻao e hoʻoholo ai i kona hiki ke therapeutic a me ke kūpono no ka hoʻomohala hou ʻana ma ke ʻano he huahana lāʻau lapaʻau. Ma keʻano holoʻokoʻa, ʻo ka (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride kahi hui waiwai nui i ka noiʻi kemika lāʻau lapaʻau, e hāʻawi ana i nā manawa kūpono no ka ʻike ʻana i ka lāʻau lapaʻau, ka hoʻonui ʻana i ke alakaʻi, a me ka hana hou therapeutic i ka ʻimi e hoʻoponopono i nā kūlana olakino paʻakikī a hoʻomaikaʻi i nā hopena o ka mea maʻi.