3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine CAS:666816-98-4

Hoʻohui ʻia ma o nā ʻano hana organik paʻakikī, hōʻike ʻo 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine i kahi hoʻolālā molekala kūikawā koʻikoʻi no nā noi like ʻole. ʻO ka scaffold xanthine, i hoʻololi ʻia e nā hui bromine, methyl, a me butynyl, e hoʻohuli i kona reactivity kemika, solubility, a me nā pilina me nā ʻōnaehana olaola. He mea nui kēia mau ʻano kūkulu no ka hoʻomaopopo ʻana i kāna ʻano pharmacological a me ka hiki ke therapeutic. Nā noi ma nā lāʻau lapaʻau ʻO ka paʻakikī o ke kūkulu ʻana o kēia hui e hoʻonoho iā ia ma ke alo o ka noiʻi lāʻau lapaʻau. Ua kaulana nā derivatives Xanthine no kā lākou mau hana pharmacological, me ka inhibition phosphodiesterase a me ka modulation adenosine receptor. ʻO ka hoʻohui ʻana o nā hui bromine, methyl, a me butynyl i loko o 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine e hoʻonui i kāna spectrum hana olaola a me ka hiki ke therapeutic, e lilo ia i moho hoʻohiki no ka hoʻomohala ʻana i ka lāʻau lapaʻau ma nā pahuhopu maʻi like ʻole. Hana Olaola a me nā ʻano Hana Hōʻike ka noiʻi e hoʻopuka nā derivatives xanthine i ko lākou hopena ma o nā ʻano hana e like me ka inhibition enzyme a me ka antagonism receptor. ʻO nā pani kikoʻī ma ka 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine e hoʻololi paha i kona kūpaʻa metabolic, ka ʻaoʻao pharmacokinetic, a me ke kikoʻī o ka pahuhopu, e hoʻohuli ana i kona pono a me ka palekana i nā noi therapeutic. He mea nui ka hoʻomaopopo ʻana i kēia mau ʻano hana no ka hoʻonui ʻana i kāna pono therapeutic. Nā Ala Synthetic a me ka Hoʻomohala ʻana ʻO ka synthesis o 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine e pili ana i nā ala organik paʻakikī e hoʻomaka ana mai nā precursors xanthine a me nā mea alkynylating. He mea nui ka hoʻonui ʻana i kēia mau ala synthetic no ka hoʻokō ʻana i ka maʻemaʻe kiʻekiʻe a me nā hua, koʻikoʻi no ka hana ʻana ma ka pae ʻoihana a me nā noi lāʻau lapaʻau. Hoʻolaha pū ka hoʻomaʻemaʻe ʻana i ka synthesis i ka pono o ke kumukūʻai a me ka hoʻomau ʻana i ka ʻike ʻana i nā lāʻau lapaʻau a me nā hana hoʻomohala. Noiʻi o kēia manawa a me nā kuhikuhi e hiki mai ana Ke nānā nei nā hana noiʻi o kēia manawa i ka ʻimi ʻana i nā hana olaola piha o ka hui, me nā hopena anti-inflammatory a i ʻole nā ​​​​waiwai neuroprotective. Hiki i nā noiʻi e hiki mai ana ke ʻeli i nā hoʻololi kūkulu e hoʻomaikaʻi i kāna ʻano pharmacokinetic a hoʻonui paha i kona koho ʻana i nā pahuhopu maʻi kikoʻī. Eia kekahi, ʻo nā haʻawina e hoʻomau nei e manaʻo e hōʻoia i kona palekana a me ka pono ma o nā loiloi preclinical a me nā lapaʻau koʻikoʻi, e hoʻomākaukau ana i ke ala no kāna noi therapeutic. Hopena I ka hopena, hōʻike ka 3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine i kahi holomua koʻikoʻi i ka kemika lāʻau lapaʻau a me ka noiʻi lāʻau lapaʻau ma muli o kona ʻano kemika paʻakikī a me nā noi therapeutic hiki. ʻO ka hoʻohui ʻana o nā hui bromine, methyl, a me butynyl i loko o kahi ʻōnaehana xanthine e hōʻike ana i kona versatility pharmacological a me ka hoʻohiki. ʻO ka wehewehe hou ʻana i kona mau waiwai kemika, nā pilina olaola, a me nā ala synthetic he mea nui ia no ka hoʻohana piha ʻana i kona hiki ke therapeutic a me ka hoʻolaha ʻana i kāna mau noi i ka lāʻau lapaʻau a me nā kahua pili.