8-Bromo-3-methyl-xanthine CAS:93703-24-3

Hoʻohui ʻia ma o nā ʻano hana organik kūikawā, loaʻa i ka 8-bromo-3-methyl-xanthine kahi hoʻolālā molekala ʻokoʻa koʻikoʻi no kāna mau noi like ʻole. ʻO ke ʻano xanthine, i hoʻololi ʻia e nā hui bromine a me methyl, e hoʻohuli i kona reactivity kemika, solubility, a me nā pilina me nā ʻōnaehana olaola. He mea nui kēia mau ʻano kūkulu no ka hoʻomaopopo ʻana i kāna ʻano pharmacological a me ka hiki ke therapeutic. Nā noi ma nā lāʻau lapaʻau Loaʻa i kēia hui ka hoʻohiki i ka noiʻi lāʻau lapaʻau ma muli o kona ʻano kūkulu. Ua ʻike ʻia nā derivatives Xanthine no kā lākou mau hana pharmacological like ʻole, me nā mea hoʻopaʻa phosphodiesterase a me nā antagonists receptor adenosine. ʻO ka hui pū ʻana o nā hui bromine a me methyl ma 8-bromo-3-methyl-xanthine e hoʻonui i kāna hana olaola a hoʻopilikia i kona ʻano hana, e lilo ia i moho no ka hoʻomohala lāʻau lapaʻau e hiki mai ana e kuhikuhi ana i nā maʻi like ʻole. Hana Olaola a me nā ʻano Hana Hōʻike nā haʻawina e launa pū nā derivatives xanthine me nā pahuhopu olaola ma o nā ʻano hana e like me ka modulation enzyme a me ka hoʻopaʻa ʻana o ka receptor. Hiki i nā bromine a me methyl substitutions ma 8-bromo-3-methyl-xanthine ke hoʻohuli i kona ikaika, ka paʻa metabolic, a me nā waiwai pharmacokinetic, e hoʻopilikia ana i kona pono a me ka palekana i nā noi therapeutic. ʻO ka hoʻomaopopo ʻana i kēia mau ʻano hana he mea nui ia no ka hoʻonui ʻana i kona hiki ke hoʻōla. Nā Ala Synthetic a me ka Hoʻomohala ʻana ʻO ka synthesis o 8-bromo-3-methyl-xanthine e pili ana i nā kaʻina hana organik paʻakikī e hoʻomaka ana mai ka xanthine a me nā mea bromo-methylating. He mea nui ka hoʻonui ʻana i nā ala synthetic no ka hoʻokō ʻana i ka maʻemaʻe kiʻekiʻe a me nā hua, koʻikoʻi no ka hana ʻana i nā ʻoihana ʻoihana a me nā noi lāʻau lapaʻau. Hoʻonui pū ka hoʻomaʻemaʻe ʻana i nā ala synthesis i ka pono o ke kumukūʻai a me ka hoʻomau ʻana i ka ʻike ʻana i nā lāʻau lapaʻau a me ka hoʻomohala ʻana. Noiʻi o kēia manawa a me nā kuhikuhi e hiki mai ana Ke kālele nei nā hana noiʻi o kēia manawa i ka ʻimi ʻana i nā hana olaola piha o ka hui, me kona hiki ke lilo i mea anti-inflammatory a i ʻole kona pono i nā therapies neuroprotective. Hiki i nā haʻawina e hiki mai ana ke noiʻi i nā hoʻololi kūkulu e hoʻomaikaʻi i kāna ʻano pharmacokinetic a hoʻonui paha i ka kikoʻī i nā pahuhopu maʻi kikoʻī. Eia kekahi, ke manaʻo nei ka noiʻi e hoʻomau nei e hōʻoia i kona palekana a me ka pono ma o nā loiloi preclinical a me nā lapaʻau koʻikoʻi. Hopena I ka hopena, hōʻike ʻo 8-bromo-3-methyl-xanthine i kahi hui koʻikoʻi i ka kemika lāʻau lapaʻau a me ka noiʻi lāʻau lapaʻau ma muli o kona ʻano kemika ʻokoʻa a me nā noi therapeutic hiki. ʻO kona hoʻohui ʻana i nā hui bromine a me methyl i loko o kahi ʻōnaehana xanthine e hōʻike ana i kāna ʻōlelo hoʻohiki pharmacological a me ka versatility. ʻO ka hoʻoikaika ʻana i ko mākou ʻike i kāna ʻano kemika, nā pilina olaola, a me nā ala synthetic he mea nui ia no ka hoʻohana ʻana i kona hiki ke hoʻōla piha a me ka hoʻolaha ʻana i kāna mau noi i ka lāʻau lapaʻau a me nā ʻoihana pili.