ʻAcetylcholinesterase CAS:9000-81-1

ʻO ka hopena anticholinesterase e pili ana i ka hiki o kekahi mau lāʻau lapaʻau a i ʻole nā ​​​​kemika ke kāohi i ka hana o ka enzyme acetylcholinesterase. ʻO Acetylcholinesterase ke kuleana no ka wāwahi ʻana i ka neurotransmitter acetylcholine i loko o ke kino. Ma ka pale ʻana i kēia enzyme, hoʻonui nā anticholinesterases i nā pae o ka acetylcholine, e alakaʻi ana i ka hoʻonui ʻana i ka hana cholinergic.

ʻO ka hoʻohana mua ʻana o nā anticholinesterases i ka mālama ʻana i nā kūlana i hōʻike ʻia e ka emi ʻana o ka hana cholinergic. ʻO kēia mau mea e komo pū me nā maʻi neurological e like me ka maʻi Alzheimer a me ka myasthenia gravis. I ka maʻi Alzheimer, hoʻohana ʻia nā anticholinesterases e like me donepezil, rivastigmine, a me galantamine e kāohi i ka haki ʻana o ka acetylcholine a hoʻonui i ka neurotransmission cholinergic. Hiki i kēia ke kōkua i ka hoʻomaikaʻi ʻana i ka hana cognitive a hiki ke hoʻolohi i ka holomua o ka maʻi.

I ka myasthenia gravis, hoʻohana ʻia nā anticholinesterases e like me neostigmine a me pyridostigmine e hoʻoikaika i ka hoʻoili ʻana o ka neuromuscular. Hoʻopaʻa kēia mau lāʻau i ka acetylcholinesterase a hoʻonui i nā pae o ka acetylcholine ma ka neuromuscular junction, e hoʻomaikaʻi ana i ka ikaika o nā ʻiʻo a me ka hōʻemi ʻana i ka nāwaliwali o nā ʻiʻo.

Loaʻa i nā Anticholinesterases nā noi diagnostic a me nā therapeutic i nā hihia o ka lāʻau make anticholinergic. ʻO nā hui Anticholinergic, e like me kekahi mau insecticides a i ʻole nā ​​​​mea nerve, hiki ke hana i ka blockade cholinergic nui e alakaʻi ana i nā hōʻailona e like me ka huikau, ka puʻuwai wikiwiki, ka waha maloʻo, a me ka ʻike maka pohihihi. I ia mau hihia, hiki ke hoʻohana ʻia nā anticholinesterases e like me pralidoxime e hoʻohuli i nā hopena ma ka hoʻonui ʻana i nā pae acetylcholine a me ka hoʻokūkū me nā mea ʻawahia.