ʻAcetylthiocholine iodide CAS:1866-15-5

Hoʻohana nui ʻia ka Acetylthiocholine iodide ma ke ʻano he substrate e ana i ka hana o ka enzyme acetylcholinesterase (AChE). ʻO AChE ke kuleana no ka wāwahi ʻana i ka neurotransmitter acetylcholine i loko o ka ʻōnaehana nerve. ʻO ka hoʻohui ʻana o ka acetylthiocholine iodide i kahi hui hopena e loaʻa ana iā AChE e alakaʻi i ka hana ʻana o ka thiocholine a me ka acetate.

Hiki ke ʻike ʻia ka hopena ma ka hoʻohui ʻana i kahi hōʻailona colorimetric a fluorometric paha e hana pololei me ka thiocholine. ʻO ka wikiwiki o ka hana kala a i ʻole ka fluorescence e pili pono ana i ka hana o AChE i loko o ka laʻana. ʻO kēia ka mea e lilo ai ka acetylthiocholine iodide i mea hana waiwai no ke ana ʻana i ka hana AChE i nā laʻana olaola like ʻole, me nā ʻiʻo, nā moʻomeheu cell, a me ke koko.

Hoʻohana nui ʻia ke ana ʻana o ka hana AChE me ka hoʻohana ʻana i ka acetylthiocholine iodide i nā haʻawina noiʻi e pili ana i nā ʻōnaehana cholinergic, nā maʻi neurodegenerative, a me ka ʻike ʻana i kekahi mau kemika a lāʻau lapaʻau paha e hoʻopilikia paha i ka hana AChE. Hiki ke hoʻohana ʻia ma ke ʻano he mea hana nānā no ka ʻike ʻana i nā mea hoʻopaʻa AChE, he mea hoihoi ia i ka hoʻomohala ʻana i nā lāʻau lapaʻau no nā maʻi e like me Alzheimer's a me Parkinson's.

Ma waho aʻe o ka hoʻohana ʻia ʻana i nā hoʻāʻo enzymatic, hiki ke hoʻohana ʻia ka acetylthiocholine iodide ma ke ʻano he substrate no nā biosensors e pili ana i ka AChE. Ua hoʻolālā ʻia kēia mau biosensors e ʻike a helu i ke alo o kekahi mau mea e hiki ke kāohi i ka hana AChE, e like me nā pesticides organophosphate a i ʻole nā ​​​​​​mea nerve.