Candesartan CAS:139481-59-7 Mea Hoʻolako Mea Hana

ʻO Candesartan kahi mea antagonist koho AT1 (angiotensin II receptor 1).ʻO ka antagonism o nā mea hoʻokipa angiotensin e kāohi i ka vasoconstriction a me ka hana ʻana o aldosterone, e alakaʻi ana i ka emi ʻana o ka wai a me ka sodium i loko o ke koko koko.Hōʻike i nā hopena antihypertensive i nā ʻano holoholona.Hoʻohana ʻia i ka mālama ʻana i ka puʻuwai congestive, ma ke ʻano he antihypertensive.ʻAʻole pili ʻo Candesartan i ka ola o ka cell a i ʻole proliferation akā hoʻonui i ka hōʻike o VEGF a me interleukin-8 i loko o ka moʻomeheu moʻomeheu o nā cell KU-19-19.Hiki i ka Candesartan (0.1 nM) ke hoʻemi i ka pane contractile maximal i ka angiostensin II ma kahi o 50%.