ʻO Candesartana Cilexetila CAS:145040-37-5

ʻO Candesartan cilexetil kahi prodrug o ka angiotensin II type 1 receptor antagonist AT1 ikaika, hana lōʻihi, a koho. Hoʻoheheʻe koke ʻia ia i candesartan i ka wā o ka omo ʻana o ka ʻōpū. Ma hope o ka hydrolysis o candesartan cilexetil i candesartan i ka wā o ka omo ʻana o ka ʻōpū, hoʻokūkū koho ʻo candesartan me ka angiotensin II no ka hoʻopaʻa ʻana o ka angiotensin II receptor subtype 1 AT1 i loko o nā ʻiʻo laumania vascular, e ālai ana i ka vasoconstriction i hoʻopili ʻia e ka angiotensin II a me ka hoʻoulu ʻana i ka vasodilatation. Eia kekahi, ʻo ka antagonism o AT1 i loko o ka adrenal gland e kāohi i ka synthesis aldosterone i hoʻoulu ʻia e ka angiotensin II a me ka huna ʻana e ka adrenal cortex; hoʻonui ka sodium a me ka excretion wai, a ukali ʻia e ka emi ʻana o ka nui o ka plasma a me ke koko.