Candesartan CAS:139481-59-7 Mea Hana Mea Hoʻolako

He antagonist koho ʻo Candesartan i ka AT1 (angiotensin II receptor 1). Hoʻopaʻa ka antagonism o nā angiotensin receptors i ka vasoconstriction a me ka hana ʻana o ka aldosterone, e alakaʻi ana i ka emi ʻana o ka wai a me ka sodium i loko o ke koko koko. Hōʻike i nā hopena antihypertensive i nā hiʻohiʻona holoholona. Hoʻohana ʻia i ka mālama ʻana i ka hāʻule ʻana o ka puʻuwai congestive, ma ke ʻano he antihypertensive. ʻAʻole hoʻopilikia ʻo Candesartan i ke ola o nā cell a i ʻole ka hoʻonui ʻana akā hoʻonui i ka hōʻike ʻana o VEGF a me interleukin-8 i loko o ka medium i hoʻoulu ʻia o nā cell KU-19-19. Hiki iā Candesartan (0.1 nM) ke hōʻemi i ka pane contractile maximal i ka angiotensin II ma kahi o 50%.