ʻEthionamide CAS:536-33-4

He mea koʻikoʻi ka Ethionamide i ka hoʻokele ʻana i ka maʻi tuberculosis multidrug-resistant (MDR-TB) a me ka maʻi tuberculosis extensively drug-resistant (XDR-TB), ʻelua ʻano o ka TB i kūʻē i nā lāʻau lapaʻau laina mua maʻamau. Hoʻohana pinepine ʻia kēia antibiotic ma ke ʻano he ʻāpana o kahi regimen lapaʻau piha e pili ana i nā lāʻau lapaʻau he nui e hakakā i nā maʻi TB ikaika i hoʻokumu ʻia e nā ʻano lāʻau lapaʻau. Hana ʻo Ethionamide ma ka hoʻopilikia ʻana i ka synthesis o nā waikawa mycolic i loko o ka paia cell bacteria o Mycobacterium tuberculosis, no laila e pale ana i ka ulu ʻana o ka bacteria a me ka hana hou ʻana. He mea nui e hahai i ka dosage i kuhikuhi ʻia a hoʻopau i ka papa hana piha o ka lāʻau lapaʻau e hoʻokō i nā hopena therapeutic maikaʻi loa a pale i ka hoʻomohala ʻana o ke kūʻē ʻana i ka lāʻau lapaʻau. ʻO nā hopena ʻaoʻao maʻamau o ka ethionamide e komo pū me nā pilikia gastrointestinal e like me ka nausea, ka luaʻi ʻana, a me ka ʻeha o ka ʻōpū, a me nā hōʻailona neurological e like me ka neuropathy peripheral. Pono ka nānā mau ʻana e nā mea lawelawe olakino e loiloi i ka pono o ka lāʻau lapaʻau a hoʻokele koke i nā hopena maikaʻi ʻole. Pono nā mea maʻi e pili pono i kā lākou regimen lapaʻau a me nā manawa hahai e nānā i ka holomua a hōʻoia i ka hoʻōla holomua mai ka maʻi TB. He kuleana koʻikoʻi ko Ethionamide i ka hakakā ʻana i ka maʻi puʻupuʻu kū i ka lāʻau lapaʻau a hōʻike i ke koʻikoʻi o kahi ala multidrug i ka hoʻoponopono ʻana i ke kaumaha honua o kēia maʻi lele.