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ʻAdenosine CAS:58-61-7
ʻO Adenosine kahi nucleoside i haku ʻia me ka adenine a me ka ribose, e pāʻani ana i kahi kuleana koʻikoʻi i ka metabolism cellular. Hana ia ma ke ʻano he poloka kūkulu kumu no ka adenosine triphosphate (ATP), ke kālā ikehu mua i nā ʻōnaehana olaola. Ma waho aʻe o kāna mau hana e pili ana i ka ikehu, pili ka adenosine i nā kaʻina hana physiological like ʻole, me ka neurotransmission, vasodilation, a me ka hoʻoponopono ʻana o ke kaʻina hiamoe-ala. Hana ia ma nā mea loaʻa kikoʻī, e hoʻohuli ana i ka helu o ka puʻuwai a me ke kahe koko. Ma ke ʻano lapaʻau, hoʻohana ʻia ka adenosine i ka lāʻau lapaʻau, ʻoi aku hoʻi i ka mālama ʻana i kekahi mau arrhythmias cardiac. Hōʻike kāna mau kuleana multifaceted i ke koʻikoʻi o ka adenosine i ke olakino a me nā maʻi.
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ʻUridine 5-monophosphate, paʻakai disodium CAS: 3387-36-8
ʻO Uridine 5-monophosphate, disodium salt (UMP) kahi nucleotide e pāʻani ana i kahi kuleana koʻikoʻi i ka metabolism cellular a me ka synthesis RNA. Me ka pyrimidine base uracil, kahi kō ribose, a me kahi hui phosphate, he mea nui ka UMP no nā kaʻina hana olaola like ʻole, me ka hoʻokumu ʻana o nā waikawa nucleic a me ka hoʻoponopono ʻana i nā ala metabolic. Hoʻonui ke ʻano paʻakai disodium i kona solubility a me ke kūpaʻa i nā hopena wai, e kūpono ai no ka noiʻi hale hana a me nā noi therapeutic. Ua loaʻa iā UMP ka nānā no kona mau waiwai neuroprotective a me ka hoʻonui ʻana i ka cognitive, a me kāna kuleana i ka hoʻolaha ʻana i ke olakino cellular holoʻokoʻa.
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Cytidine 5′-(disodium phosphate) CAS:6757-06-8
ʻO Cytidine 5′-(disodium phosphate) kahi nucleotide derivative i haku ʻia me ka pyrimidine base cytosine, ke kō ribose, a me kahi hui phosphate. He kuleana koʻikoʻi kēia hui i nā kaʻina hana biochemical like ʻole, me ka RNA synthesis, nā ala hoʻoponopono, a me ka hōʻailona cellular. Hoʻonui ke ʻano paʻakai disodium i kona solubility a me ke kūpaʻa i nā kūlana physiological, e kūpono ai no ka noiʻi hale hana a me nā noi therapeutic hiki. Ua loaʻa i ka Cytidine 5′-(disodium phosphate) ka hoihoi no kona komo ʻana i ka metabolism nucleic acid a me kona mau pono kūpono i ka hoʻoikaika ʻana i ka hana cognitive a me ke kākoʻo ʻana i ke olakino cellular.
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5-Azacytidine CAS:320-67-2
ʻO 5-Azacytidine kahi analogue nucleoside synthetic o cytidine nona kahi ʻātoma nitrogen ma ke kūlana 5 o ke apo pyrimidine, e pani ana i kahi ʻātoma kalapona. Hāʻawi kēia hoʻololi i nā waiwai pharmacological kū hoʻokahi, e lilo ia i hui koʻikoʻi i ka biology molecular a me ka lāʻau lapaʻau maʻi kanesa. Ma ke ʻano he mea hoʻopaʻa ikaika i ka DNA methyltransferase, hiki i ka 5-azacytidine ke hoʻāla hou i nā genes i hoʻopau ʻia ma ka hoʻololi ʻana i nā ʻano methylation DNA, a laila e hoʻohuli i ka hōʻike ʻana o ka gene. I hoʻomohala mua ʻia no ka mālama ʻana i nā maʻi hematologic, ua loaʻa i ka 5-azacytidine ka nānā ʻana no kāna mau noi hiki i ka lāʻau lapaʻau epigenetic, ka lāʻau lapaʻau regenerative, a me ka noiʻi e pili ana i nā maʻi like ʻole i hōʻailona ʻia e ka hoʻoponopono ʻana o nā genes maʻamau.
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2′-Fluoro-2′-deoxyuridine CAS:784-71-4
ʻO 2′-Fluoro-2′-deoxyuridine (FdU) kahi analog nucleoside o deoxyuridine, kahi i pani ʻia ai ka ʻātoma hydrogen ma ke kūlana 2′ o ke kō ribose e kahi ʻātoma fluorine. Hoʻonui kēia hoʻololi i ke kūpaʻa a me ka bioactivity o ka hui, e lilo ia i mea waiwai nui i ka noiʻi biochemical a me nā noi therapeutic. Ua kaulana ʻo FdU no kāna kuleana ma ke ʻano he antiviral a me anticancer agent, no ka mea hiki iā ia ke hoʻopilikia i ka synthesis DNA a kāohi i ka hana hou ʻana o kekahi mau virus a me nā cell cancer. ʻO kona mau waiwai kū hoʻokahi e lilo ia i mea hana koʻikoʻi i ka hoʻomohala ʻana i nā therapies i kuhikuhi ʻia a me nā haʻawina biology molecular.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
ʻO 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one kahi analog nucleoside paʻakikī e hōʻike ana i kahi kumu pyrimidine i hoʻopili ʻia i kahi kō ribose i hoʻololi ʻia. ʻO ke alo o kahi ʻātoma fluorine a me nā hui hydroxyl i loko o kona ʻano e hoʻonui ai i kona mau waiwai biochemical, e lilo ia i moho hoihoi no ka noiʻi antiviral a me anticancer. Loaʻa i kēia hui nā noi kūpono i ka kemika lāʻau lapaʻau, ʻoiai ma ke ʻano he mea therapeutic e kuhikuhi ana i ka synthesis acid nucleic a me nā ala metabolic i nā meaola pathogenic. ʻO kona mau ʻano hoʻonohonoho kū hoʻokahi e ʻae ai i ka launa pū ʻana me nā pahuhopu olaola e pili ana i ka metabolism DNA a me RNA.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
ʻO 1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose kahi ʻano ribose i hoʻololi ʻia i ke kemika, e hōʻike ana i ʻekolu mau hui benzoyloxy i hoʻopili ʻia i nā kūlana 1, 3, a me 5 o ka ʻano ribofuranose. Hoʻonui kēia hoʻololi i kona solubility a me ke kūpaʻa, e lilo ia i mea pono i nā noi synthetic like ʻole i ka kemika organik a me ka biochemistry. Ma ke ʻano he derivative pale ʻia o ka ribose, lawelawe ia ma ke ʻano he waena i ka synthesis o nā nucleosides a me nā nucleotides, nā ʻāpana koʻikoʻi o RNA a me DNA. ʻO kona mau waiwai kū hoʻokahi e lilo ai ka 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose i mea waiwai no nā mea noiʻi e ʻimi nei e hoʻomohala i nā mea lapaʻau hou a me nā mea hana i ka kemika nucleotide.
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2′-O-methyluridine CAS:2140-76-3
ʻO 2′-O-Methyluridine kahi nucleoside kūlohelohe kahi i hoʻopili ʻia ai kahi hui methyl i ka ʻātoma oxygen o ke kūlana 2′ o ke kō ribose i loko o ka uridine. Hoʻonui kēia hoʻololi i ke kūpaʻa a me ka hana o nā molekala RNA, e lilo ia i mea koʻikoʻi i nā kaʻina hana olaola like ʻole. He kuleana koʻikoʻi ko 2′-O-Methyluridine i ke ʻano a me ka hana o nā waikawa ribonucleic (RNA), me ka messenger RNA (mRNA) a me ka transfer RNA (tRNA). Hiki i kona alo ke hoʻohuli i ke kūpaʻa o ka RNA, ka pono o ka unuhi ʻana, a me nā pilina me nā protein a me nā waikawa nucleic ʻē aʻe, e lilo ia i mea koʻikoʻi i ke aʻo ʻana i ka biology molecular a me nā noi therapeutic.
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adenosine 5′-monophosphate sodium*mai ka hū CAS:4578-31-8
ʻO Adenosine 5′-monophosphate sodium (AMP) kahi nucleotide i loaʻa mai ka adenosine e pāʻani ana i kahi kuleana koʻikoʻi i ka metabolism cellular. He mea nui ka AMP no nā kaʻina hana olaola like ʻole, me ka hoʻoili ikehu, ka transduction hōʻailona, a ma ke ʻano he precursor no ka synthesis o ATP a me nā nucleotides ʻē aʻe. Hiki ke loaʻa ke ʻano paʻakai sodium o AMP mai ka hū, ka mea waiwai i nā nucleotides ma muli o kona mau ala metabolic ikaika. Hoʻohana pinepine ʻia kēia hui i ka biochemistry a me ka pharmacology ma ke ʻano he reagent biochemical, mea hoʻohui meaʻai, a me ka mea hoʻohui meaʻai, ma muli o kona mau pono olakino a me nā noi i ka hoʻolaha ʻana i ka metabolism ikehu.
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2′-Deoxycytidine CAS:951-77-9
ʻO 2′-Deoxycytidine kahi nucleoside i haku ʻia me ke kō deoxyribose a me ka cytosine, i hoʻokaʻawale ʻia e ka loaʻa ʻole o kahi hui hydroxyl ma ke kūlana 2′ o ka ribose. ʻO kēia hoʻololi ʻana e lilo ia i ʻāpana koʻikoʻi o ka DNA, kahi e hui pū ai me ka guanine i ka wā o ka hui ʻana o ke kumu. He kuleana koʻikoʻi ko 2′-Deoxycytidine i ka metabolism cellular a me ka synthesis DNA, e lawelawe ana ma ke ʻano he poloka kūkulu no ka deoxycytidine triphosphate (dCTP), he mea koʻikoʻi no ka hana hou ʻana a me ka hoʻoponopono ʻana o ka DNA. Eia kekahi, he mau hopena koʻikoʻi kēia nucleoside i ka noiʻi biology molecular, ka lāʻau lapaʻau maʻi kanesa, a me nā hoʻolālā antiviral, e hōʻike ana i kona pili i nā noiʻi kumu a me nā noi lapaʻau.
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2,2′-cyclouridine CAS:3736-77-4
ʻO 2,2′-Cyclouridine kahi bicyclic nucleoside derivative o uridine, i hōʻike ʻia e ka hoʻokumu ʻana o kahi ʻano cyclic kū hoʻokahi e pili ana i nā kūlana 2′ a me 2” o ka ʻāpana ribose. Hāʻawi kēia hoʻololi ʻana i ke ʻano i nā waiwai biochemical ʻokoʻa e hoʻohuli i kona kūpaʻa a me ka hana olaola. Ua loaʻa i ka 2,2′-Cyclouridine ka hoihoi i ka biology kemika a me ka kemika lāʻau lapaʻau ma muli o kāna mau noi hiki ke lilo i mea antiviral a ma ka noiʻi RNA. ʻO kona hiki ke hoʻololi i nā pilina waikawa nucleic e lilo ia i mea hana waiwai no ke aʻo ʻana i nā pilina RNA structure-function, hiki ke alakaʻi i nā holomua i nā hoʻolālā therapeutic e kuhikuhi ana i nā maʻi viral a me nā maʻi genetic.
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2-Aminoadenosine CAS:2096-10-8
ʻO 2-Aminoadenosine kahi nucleoside derivative kūlohelohe o adenosine, i hoʻokaʻawale ʻia e ke alo o kahi hui amino ma ke kūlana 2 o ke kō ribose. Hoʻololi nui kēia hoʻololi i kona mau waiwai biochemical a me nā hana, e lilo ia i molekala koʻikoʻi i nā kaʻina hana physiological like ʻole. Pili ʻo 2-Aminoadenosine i ka hōʻailona cellular, metabolism, a me nā ala hoʻoponopono, me nā mea e pili ana i ka homeostasis ikehu a me ka neurotransmission. ʻO kāna mau noi therapeutic hiki ke uhi i nā ʻano like ʻole, me ka neurobiology a me ka cardiology, kahi e hoʻohuli ai i nā pane cellular i ke kaumaha a me ka hōʻeha. Ke hoʻomau nei ka noiʻi, ua paʻa ka 2-aminoadenosine i ka hoʻohiki no ka hoʻomohala ʻana i nā hui bioactive hou a me nā mea therapeutic.
