ʻO ka L-Lactate dehydrogenase CAS:9001-60-9

ʻO ka hopena o ka L-Lactate dehydrogenase (LDH) e komo pū ana me kāna kuleana i ka metabolism ikehu cellular a me kona komo ʻana i ka hoʻololi ʻana o pyruvate i lactate. Kōkua ʻo LDH i ka mālama ʻana i ke kaulike ikehu i loko o nā cell ma ka hoʻomaʻamaʻa ʻana i ka hoʻololi ʻana o pyruvate, kahi huahana o ka metabolism glucose, i lactate. Hana ʻia kēia kaʻina hana, i ʻike ʻia ʻo anaerobic glycolysis, ke kaupalena ʻia ka lako oxygen.

He kuleana koʻikoʻi ko LDH i ka hana hou ʻana o ka lactate. I ka wā o ka hoʻoikaika kino nui a i ʻole ka haʻahaʻa o ka loaʻa ʻana o ka oxygen, hiki i ka lactate ke hōʻiliʻili i loko o nā ʻiʻo. Kōkua ʻo LDH i ka hana hou ʻana i ka lactate ma ka hoʻololi ʻana iā ia i pyruvate, a laila hiki ke hoʻohana ʻia ma ke ʻano he substrate no ka hana ʻana i ka ikehu a i ʻole e hoʻololi ʻia i glucose ma o ka gluconeogenesis. ʻAe kēia ʻano hana hana hou lactate i nā cell e hoʻohana pono i ka lactate ma ke ʻano he kumu ikehu a kōkua i ka pale ʻana i ka hōʻiliʻili ʻana o ka lactate, hiki ke hōʻino i ka hana o ke kelepona.

He nui nā noi o LDH ma ke kahua lapaʻau. ʻO kekahi o kāna mau noi nui, ʻo ia ke ʻano he māka hōʻailona no kekahi mau maʻi. Hiki i nā pae kiʻekiʻe o LDH i loko o ke koko ke hōʻike i ka hōʻino ʻia o nā ʻiʻo a i ʻole ke alo o nā maʻi e like me ka hōʻino ʻia o ke akepaʻa, ka myocardial infarction, a me kekahi mau ʻano maʻi kanesa. Hoʻopaʻa pinepine ʻia nā pae LDH ma nā wahi lapaʻau e loiloi i ka holomua o ka maʻi a me ka pane ʻana i ka lāʻau lapaʻau.