Leflunomide CAS:75706-12-6 Mea Hoʻolako Mea Hana

ʻAʻole hana ʻo Leflunomide, akā ua kāohi ka teriflunomide i ka pyrimidine de novo synthesis ma nā haʻahaʻa haʻahaʻa therapeutic ma o ke kāohi ʻana i ka dihydroorotate dehydrogenase (ka enzyme e hoʻoholo ai i ka helu no ka synthesis o UMP), e hoʻemi ana i ka synthesis DNA a me RNA, a me ka hopu ʻana i ka pōʻaiapuni o ka cell proliferation a me ka hana ʻana o nā antibodies.ʻO ka hoʻemi ʻana o ka dihydroorotate i ka orotate i ka manawa like me ka hoʻemi ʻana o kāna cofactor, ubiquinone (coenzyme Q).ʻO ka pāpā ʻana o dihydroorotate dehydrogenase e teriflunomide e hōʻike ana i nā kinetics noncompetitive a me ka hoʻokūkū ʻole.ʻO ka hoʻohana ʻana i ka leflunomide i nā poʻe maʻi me ka rheumatoid arthritis ka hopena i ka neʻe ʻana o nā pūnae B a me ka hoʻoponopono ʻana i ke kaʻina hana immune.