Leflunomide CAS:75706-12-6 Mea Hana Mea Hoʻolako

ʻAʻole hana ʻo Leflunomide, akā ke kāohi nei ka teriflunomide i ka hana ʻana o ka pyrimidine de novo ma nā dosis therapeutic haʻahaʻa ma o ka pale ʻana i ka dihydroorotate dehydrogenase (ka enzyme hoʻoholo wikiwiki no ka hana ʻana o UMP), ka hoʻemi ʻana i ka hana ʻana o ka DNA a me RNA, a me ka hoʻopaʻa ʻana i ke kaʻina hana hoʻonui cell a me ka hana ʻana o nā antibodies. ʻO ka hōʻemi ʻana o ka dihydroorotate i ka orotate e hana pū ʻia me ka hōʻemi ʻana o kāna cofactor, ubiquinone (coenzyme Q). ʻO ka pale ʻana o ka dihydroorotate dehydrogenase e ka teriflunomide e hōʻike ana i nā kinetics noncompetitive a me uncompetitive. ʻO ka lawelawe ʻana o ka leflunomide i nā maʻi me ka rheumatoid arthritis e hopena i ka wehe holomua ʻana o nā cell B a me ka hoʻohaʻahaʻa ʻana o ke kaʻina hana pale.