Natamycin/Pimaricin CAS:7681-93-8 Mea Hana Mea Hoʻolako

ʻO Pimaricin kahi macrocyclic tetraene i hoʻokaʻawale mua ʻia mai Streptomyces natalensis i ka makahiki 1957. Hōʻike ʻo Pimaricin i ka hana antifungal ākea ākea e kūʻē i ka hū a me nā fungi filamentous ma o ka hoʻopaʻa ʻana i ka ergosterol e ālai i ka ulu ʻana o ka fungal. ʻAʻole like me nā polyenes pili, nystatin a me filipin, ʻaʻole hoʻololi ka pimaricin i ka permeability o ka membrane plasma. Hoʻohana ʻia ʻo Pimaricin i ka ʻoihana meaʻai no ka mālama ʻana i nā tīhi ma ke ʻano he mea hoʻopaʻa mold. ʻO Natamycin kahi antibiotic polyene semisynthetic. ʻAʻole maikaʻi ka wai o Natamycin a ʻaʻole e komo i loko o ka epithelium corneal i hoʻopaʻa ʻia. ʻO Natamycin wale nō ka mea antifungal i ʻae ʻia no ka hoʻohana ʻana ma ka maka a ʻo ia wale nō ka lāʻau maka i loaʻa no ka mālama ʻana i ka fungal keratitis. ʻO Natamycin, i ʻike ʻia ʻo pimaracin, no ka ʻohana polyene o nā antibiotics; (kahi hui o nā mea antifungal e kuhikuhi a hoʻopaʻa i nā sterols eukaryotic a me ka ergosterol), a he metabolite lua ia o Streptomyces natalensis.