ʻO ka reagent Neocuproine kahi reagent no ka hoʻoholo ʻana i ke keleawe, keʻokeʻo a melemele-ʻeleʻele paha, hoʻonāukiuki. Hoʻohana nui ʻia ma ke ʻano he reagent no ka hoʻoholo ʻana i ke cuprous, ka hoʻoholo photometric o ke keleawe, ka hoʻoholo ʻana i ke kō koko ultra-micro; synthesis organik. Ua hoʻohana ʻia ʻo Neocuproine hydrochloride monohydrate i ke ana ʻana i ka hoʻoheheʻe ʻana o ke keleawe i loko o nā alloys Cu-Ni me ka hoʻohana ʻana i ke ʻano colorimetric. Ua hoʻohana ʻia hoʻi i ka hoʻomākaukau ʻana i ka hopena complexing agent i ke aʻo ʻana i nā assays capacity antioxidant i nā laʻana olaola e pili ana i nā complexes Cu reducing. Hiki ke hoʻohana ʻia ma ke ʻano he precursor no ka hoʻomākaukau ʻana o ka neocuproine, i hoʻohana ʻia ma ke ʻano he reagent analytical no ka hoʻoholo ʻana i ke keleawe i nā laʻana kaiapuni me ka hoʻohana ʻana i ke ʻano spectrophotometric.
Akā, he ʻokoʻa loa ka hoʻohana ʻana o ia ʻano lāʻau lapaʻau i ka lāʻau lapaʻau. I kēia mau lā iho nei, ua ʻae ʻia ʻo Eribulin no ke kūʻai aku ʻana e ka National Medical Products Administration (NMPA) o koʻu ʻāina no ka mālama ʻana i nā maʻi maʻi ʻaʻai umauma e hoʻi hou ana a metastatic paha i loaʻa i ʻelua mau regimen chemotherapy (me nā anthracyclines a me nā taxans) i ka wā ma mua. Ua lawe mai ia i kahi ʻano lapaʻau hou i ke kahua o ka chemotherapy maʻi ʻaʻai umauma ma Kina, Lawe mai ia i nā koho lapaʻau hou aʻe no nā maʻi.
ʻO Eribulin kahi mea hoʻopaʻa tubulin non-taxane. ʻAʻole e like me nā mea hoʻopaʻa taxane a me vinblastine tubulin, loaʻa iā Eribulin kahi ʻano hana kūikawā, ka mea e hana ai iā Eribulin He pono nō ia i nā maʻi ma hope o ke kūʻē ʻana i ka lāʻau i ka yew; Loaʻa iā Eribulin nā hopena non-cytotoxic, me ka hoʻoponopono hou ʻana o nā vascular, ka hoʻonui ʻana i ka perfusion o nā lāʻau ʻē aʻe i loko o ka microenvironment tumor, synergizing i nā lāʻau ʻē aʻe, a me ka hoʻohuli ʻana i nā cell tumor. ʻO ka hoʻololi epidermal-mesenchymal a pēlā aku.
Mai ka synthesis holoʻokoʻa o ka halichondrin B, ka hoʻohana ʻana i nā reagents keleawe hou ma ke ʻano he mau waena, a hiki i ka hoʻololi ʻana o ke ʻano o Eribulin, a hiki i ka hana ʻoihana o Eribulin, ua hoʻolilo nā kānaka ʻepekema mai nā kula nui a me nā ʻoihana lāʻau lapaʻau i ʻoi aku ma mua o 20 mau makahiki o ka ʻimi ʻana. Ua lilo nā huahana kūlohelohe i loaʻa mai ke kai i mau lāʻau lapaʻau e hiki ke mālama i ka maʻi kanesa. ʻO ka noiʻi a me ka hoʻomohala ʻana o Eribulin no ka mea he mea nui ka reagent keleawe hou ma ke ʻano he waena nui o kāna API. He kuleana nui ko ka reagent keleawe hou ma ke ʻano he waena lāʻau lapaʻau a he reagent no ka hoʻomaʻemaʻe ʻana i nā mea hana kiʻekiʻe.
Aia i loko o ke ʻano molekala o Eribulin he 19 mau kikowaena chiral, a ʻo nā ʻanuʻu synthesis he 62 mau ʻanuʻu. A hiki i kēia manawa, ua manaʻo ʻia ʻo Eribulin e ka ʻoihana ʻo ia ka lāʻau non-peptide paʻakikī loa i hana ʻia e ka synthesis kemika maʻemaʻe, a hiki ke kapa ʻia ʻo Mount Everest i ka ʻoihana synthesis kemika.
ʻO ka papa inoa holomua o Eribulin e hōʻike ana i nā kiʻekiʻe hou e hiki ai i nā ʻoihana lāʻau lapaʻau ke hoʻokō i ka synthesis kemika a me ka hana ʻoihana. Lawe pū ia i nā manaʻo hōʻoia a me nā koho lapaʻau hou aʻe i nā kauka Kina. Manaʻolana ʻia i ka hana lapaʻau e hiki mai ana, hiki i ka lāʻau chemotherapeutic hou ʻo Eribulin ke lawe mai i ka manaʻolana hou i nā poʻe maʻi kanesa umauma.
Ka manawa hoʻouna: Ian-01-2021