ʻO Letrozole kahi ʻāpana o ka hanauna hou o nā mea hoʻopaneʻe aromatase koho nui a ʻo ia ka derivative benzotriazole i hana ʻia.Kāohi ʻo Letrozole i ka aromatase e hoʻohaʻahaʻa i nā pae estrogen, no laila e pale ai i ka estrogen mai ka hoʻoulu ʻana i ka ulu ulu.ʻO kāna hana in vivo he 150-250 mau manawa ʻoi aku ka ikaika ma mua o ka hanauna mua o ka aromatase inhibitor Amarante.No ka mea he koho nui loa ia, ʻaʻole ia e hoʻopili i nā hana glucocorticoid, mineralocorticoid a me thyroid;ʻoiai ma nā ʻano kiʻekiʻe, ʻaʻole e loaʻa nā hopena inhibiting i ka huna ʻana o ka corticosteroid adrenal, hāʻawi iā ia i kahi kuhikuhi mālama kiʻekiʻe.