ʻO Tritylolmesartanethylester CAS:144690-33-5

He mea nui ka Tritylolmesartanethylester i ke kemika lāʻau lapaʻau a me ka ʻike ʻana i nā lāʻau lapaʻau, ʻoi aku hoʻi i ka hoʻomohala ʻana o nā antagonists receptor angiotensin II me nā ʻano pharmacological i hoʻonui ʻia. Ma ke ʻano he derivative o ka lāʻau antihypertensive kaulana ʻo olmesartan medoxomil, lawelawe kēia hui ma ke ʻano he scaffold waiwai no ka synthesis a me ka loiloi ʻana o nā analogs hou me ka hoʻomaikaʻi ʻana i ka pono a me nā waiwai pharmacokinetic. I ka noiʻi lāʻau lapaʻau, ua aʻo ʻia ʻo Tritylolmesartanethylester no kona hiki ke hoʻololi i ka ʻōnaehana renin-angiotensin, kahi e pāʻani ai i kahi kuleana koʻikoʻi i ka hoʻoponopono ʻana i ke koko, ke kaulike wai, a me ka hana cardiovascular. Ma ka noiʻi ʻana i kāna mau pilina me nā receptors angiotensin II, makemake nā mea noiʻi e hoʻolālā i nā hui hou e hiki ke pale pono i nā hopena physiological o angiotensin II, e alakaʻi ana i ka hoʻomohala ʻana o nā lāʻau antihypertensive hanauna hou me nā hopena therapeutic maikaʻi aʻe a me nā hopena ʻaoʻao i hoʻemi ʻia. Eia kekahi, ʻo nā hoʻololi kūkulu a me nā loiloi pharmacological o Tritylolmesartanethylester a me kāna mau analogs e kōkua i ka hoʻomaopopo ʻana i nā pilina hana-hana (SAR) i loko o ka papa antagonist receptor angiotensin. Ke alakaʻi nei kēia ʻike i ka hoʻolālā kūpono o nā moho lāʻau lapaʻau i hoʻomaikaʻi ʻia me ka hoʻomaikaʻi ʻana i ka pilina receptor, selectivity, a me ke kūpaʻa metabolic, e hoʻomākaukau ana i ke ala no ka holomua ʻana i ka mālama ʻana i nā maʻi cardiovascular e like me ke koko kiʻekiʻe, ka hāʻule ʻana o ka puʻuwai, a me ka diabetic nephropathy. Eia kekahi, hoʻonui ʻia nā noi hiki o Tritylolmesartanethylester i nā haʻawina preclinical i manaʻo ʻia e wehewehe i kāna mau ʻano pharmacokinetic a me pharmacodynamic, nā ʻano toxicity, a me ka hiki ke therapeutic ma o nā hoʻokolohua in vitro a me in vivo. Hāʻawi kēia mau noiʻi i nā ʻikepili koʻikoʻi no ka loiloi ʻana i kona palekana a me ka pono, e kākoʻo hope ana i kona holomua i nā hoʻokolohua lapaʻau a me ka hoʻomohala lāʻau lapaʻau. I ka hōʻuluʻulu manaʻo, hoʻopili nā hoʻohana a Tritylolmesartanethylester i kāna kuleana koʻikoʻi i ka kemika lāʻau lapaʻau a me ka noiʻi lāʻau lapaʻau ma ke ʻano he kahua no ka hoʻolālā, synthesis, a me ka loiloi ʻana o nā antagonists receptor angiotensin II hou, e hāʻawi ana i ka holomua o ka lāʻau antihypertensive a me ka pharmacology cardiovascular.