ʻO ka paʻakai trisodium waikawa Uridine-5′-diphosphoglucuronic CAS: 63700-19-6

Hoʻomaʻemaʻe kino: ʻO ka waikawa UDP-glucuronic kahi molekala koʻikoʻi e pili ana i nā hopena biotransformation phase II o nā xenobiotics a me nā hui endogenous. Hana ia ma ke ʻano he precursor no ka synthesis o glucuronides, he mau conjugates wai-soluble loa hiki ke hoʻopau maʻalahi ʻia mai ke kino. Kōkua kēia kaʻina hana detoxification i ka hoʻopau ʻana a me ka hoʻopau ʻana i nā mea ʻino, e like me nā lāʻau lapaʻau, nā mea ʻawahia o ke kaiapuni, a me kekahi mau huahana metabolic.

Ka metabolism lāʻau: He nui nā lāʻau e hana ana i ka glucuronidation, kahi hana e hui pū ai ka waikawa UDP-glucuronic me ka molekole lāʻau, e hopena ana i ka hoʻokumu ʻia ʻana o kahi metabolite glucuronide. Hoʻonui pinepine kēia hopena glucuronidation i ka hoʻopau ʻana i nā lāʻau mai ke kino a hoʻomaʻalahi i ko lākou hoʻokuʻu ʻia ma o ka mimi a i ʻole ka bile. Hoʻohana pinepine ʻia ka paʻakai UDP-glucuronic acid trisodium i nā haʻawina e noiʻi ana i ka metabolism a me ka pharmacokinetics o nā lāʻau.

Mea hana noiʻi: Hoʻohana nui ʻia ka paʻakai UDP-glucuronic acid trisodium ma ke ʻano he mea hana noiʻi i nā haʻawina like ʻole e pili ana i ka metabolism lāʻau, enzymology, a me ka toxicology. Hāʻawi ia i kahi kumu o ka UDP-glucuronic acid no nā hoʻokolohua in vitro a hiki i nā mea noiʻi ke noiʻi i ka hopena o ka glucuronidation ma ka hoʻomaʻemaʻe lāʻau, bioavailability, a me nā pilina lāʻau-lāʻau.

Glycosylation: Pili pū ka waikawa UDP-glucuronic i nā hopena glycosylation, kahi e hana ai ma ke ʻano he mea hāʻawi o nā ʻāpana waikawa glucuronic no ka synthesis o glycosaminoglycans (GAGs) a me proteoglycans. He kuleana koʻikoʻi ko kēia mau molekala i nā kaʻina hana olaola like ʻole, me ka hoʻopili ʻana o nā cell, ka hoʻokumu ʻana o ka matrix extracellular, a me ka hōʻailona.