Z-Pro-ONp CAS:3304-59-4

Hoʻohana nui ʻia ʻo Z-Pro-ONp i ke kemika peptide ma ke ʻano he reagent koʻikoʻi no nā hopena hoʻopili peptide a me ka synthesis o nā peptides a me peptidomimetics. Ma ke ʻano he N-(p-nitrophenyl)oxycarbonyl (Npoc) derivative o L-proline, hoʻomaʻalahi ia i ka hoʻokomo ʻana o nā koena proline i loko o nā kaulahao peptide me ka mana pololei ma luna o nā ʻanuʻu pale a me ka deprotection. Hilinaʻi nā kemika a me nā mea noiʻi iā Z-Pro-ONp no ka synthesis peptide solid-phase a me solution-phase, e hiki ai ke kūkulu ʻia nā moʻo peptide maʻamau i hana ʻia i nā pahuhopu biological kikoʻī a i ʻole nā ​​​​kumu therapeutic. Eia kekahi, loaʻa iā Z-Pro-ONp ka noi i ka hoʻomohala ʻana o nā peptidomimetics—nā molekala i hoʻolālā ʻia e hoʻohālike i ke ʻano a me ka hana o nā peptides bioactive. Ma ka hoʻohui ʻana i nā motif i loaʻa iā Z-Pro-ONp i loko o nā ʻano peptidomimetic, hiki i nā kānaka ʻepekema ke ʻimi i nā hui hou me nā noi hiki ke hoʻohana ʻia i ka ʻike ʻana i nā lāʻau lapaʻau, ke kemika lāʻau lapaʻau, a me ka noiʻi biomedical. Eia kekahi, lawelawe ʻo Z-Pro-ONp ma ke ʻano he poloka hale koʻikoʻi i ka hana ʻana o nā lāʻau lapaʻau a me nā therapeutics e pili ana i ka peptide. ʻO kona maʻemaʻe kiʻekiʻe a me ke kūpaʻa e lilo ia i mea nui loa i ka hana ʻana i nā peptides maʻamau a me nā peptidomimetics no nā haʻawina preclinical a me nā lapaʻau, e hāʻawi ana i nā mea noiʻi me ka maʻalahi e hoʻolālā a hoʻomaikaʻi i nā ʻano peptide me ka hana olaola i hoʻonui ʻia a me nā waiwai pharmacokinetic. Ma keʻano holoʻokoʻa, hoʻokani ʻo Z-Pro-ONp i kahi kuleana koʻikoʻi i ka hoʻolaha ʻana i nā kahua o ka kemika peptide, ka ʻike lāʻau lapaʻau, a me ka hoʻomohala lāʻau lapaʻau, e hoʻoikaika ana i nā ʻepekema a me nā mea noiʻi e hoʻohana i nā hiki like ʻole o nā peptides a me nā peptidomimetics no ka therapeutic a me ka hana hou ʻepekema.