1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile CAS:2158267-70-8

He kuleana koʻikoʻi ko 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile ma ke ʻano he waena i ka synthesis o nā hui paʻakikī, bioactive me nā noi lāʻau lapaʻau. ʻO kona hoʻokomo ʻia ʻana i loko o nā ʻōnaehana molekala e hiki ai i nā mea noiʻi ke ʻimi i nā moho lāʻau lapaʻau hou e kuhikuhi ana i nā wahi therapeutic like ʻole e like me nā kinase inhibitors, fluorescent probes, a i ʻole nā ​​​​noi kemika mea. ʻO ke alo o ka pyrazole core a me ka hui dioxaborolane e hoʻolauna i ka reactivity kikoʻī a me nā waiwai pharmacophoric, e lilo ia i mea waiwai no ka noiʻi kemika lāʻau lapaʻau. I nā hana ʻike lāʻau lapaʻau, hiki i kēia hui ke lawelawe ma ke ʻano he kumu hoʻomaka no ka hoʻolālā ʻana i nā moho lāʻau lapaʻau, e hoʻohana ana i kona mau hiʻohiʻona kūkulu e hoʻololi i ka hana olaola a me nā waiwai pharmacokinetic. Eia kekahi, hāʻawi ka hui hana dioxaborolane i nā manawa kūpono no ka derivatization hou aʻe a me ke kemika cross-coupling, hiki ke alakaʻi i ka hoʻomohala ʻana o nā molekala hou me nā waiwai olaola i hoʻonui ʻia a me nā ʻaoʻao pharmacokinetic i hoʻomaikaʻi ʻia. Eia kekahi, ma nā wahi hoʻonaʻauao a me nā ʻoihana, hiki i nā mea noiʻi ke hoʻohana i kēia poloka hale e hoʻomākaukau i nā hale waihona puke o nā derivatives like ʻole no nā haʻawina pilina hana-hana, e kōkua ana i ka ʻike ʻana i nā hui alakaʻi me nā hopena olaola i makemake ʻia. ʻO kona kuleana i ka synthesis kemika e hoʻonui i ka hana ʻana o nā mea waena lāʻau lapaʻau a me ka hoʻomohala ʻana i nā ʻano hana synthetic hou, e hōʻike ana i kona pono ākea ma waena o nā aʻo ʻepekema. Ma keʻano holoʻokoʻa, he kuleana koʻikoʻi ka 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carbonitrile i ka ʻimi ʻana i ka ʻike lāʻau lapaʻau hou a me ka noiʻi kemika, e hāʻawi ana i kahi kahua no ka hoʻomohala ʻana i nā molekala olaola like ʻole a me nā mea waena lāʻau lapaʻau.