4-cyclopropylpyrrolidin-2-one CAS:126822-39-7

Hana ʻo 4-cyclopropylpyrrolidin-2-one ma ke ʻano he waena koʻikoʻi i ka synthesis o nā hui paʻakikī, bioactive me nā noi lāʻau lapaʻau hiki. ʻO kona hoʻokomo ʻia ʻana i loko o nā ʻōnaehana molekala e hiki ai i nā mea noiʻi ke ʻimi i nā moho lāʻau lapaʻau hou e kuhikuhi ana i nā wahi therapeutic like ʻole e like me nā maʻi ʻōnaehana nerve waena, ka hoʻokele ʻeha, a i ʻole nā ​​​​kūlana psychiatric. ʻO nā hiʻohiʻona hoʻonohonoho a me ka reactivity o kēia hui e lilo ia i mea waiwai no ka hoʻomohala ʻana i nā molekala pili pharmacologically. I loko o ke kemika lāʻau lapaʻau, hiki i kēia poloka hale ke lawelawe ma ke ʻano he wahi hoʻomaka no ka hoʻolālā ʻana i nā moho lāʻau lapaʻau hiki, e hoʻohana ana i kona mau waiwai hoʻonohonoho kū hoʻokahi e hoʻohuli i ka hana olaola a me nā ʻano pharmacokinetic. ʻO ke alo o ka cyclopropyl moiety e hāʻawi i nā hopena steric a me nā uila kikoʻī, e hoʻopilikia paha i nā pilina o nā hui hopena me nā pahuhopu olaola, e kōkua ana i ka ʻimi ʻana i nā lāʻau lapaʻau hou. Eia kekahi, ma nā wahi hoʻonaʻauao a me nā ʻoihana, hiki i nā mea noiʻi ke hoʻohana i kēia poloka hale e hoʻomākaukau i nā hale waihona puke o nā derivatives like ʻole no nā haʻawina pilina hana-hana, e hoʻomaʻamaʻa ana i ka ʻike ʻana i nā hui alakaʻi me nā hopena olaola i makemake ʻia. ʻO kona kuleana i ka synthesis kemika e hoʻonui i ka hana ʻana o nā waena lāʻau lapaʻau a me ka hoʻomohala ʻana i nā ʻano hana synthetic hou, e hōʻike ana i kona pono ākea ma waena o nā aʻo ʻepekema. Ma keʻano holoʻokoʻa, he kuleana koʻikoʻi ko 4-cyclopropylpyrrolidin-2-one i ka ʻimi ʻana i ka ʻike lāʻau lapaʻau hou a me ka hana hou ʻana i nā kemika, e hāʻawi ana i kahi kahua no ka hoʻomohala ʻana i nā molekala biologically active like ʻole a me nā mea waena lāʻau lapaʻau.