(6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid CAS:30246-33-4

ʻO (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, i ʻike ʻia hoʻi ʻo [insert trade or generic name if applicable], he mea nui ia i ka noiʻi lāʻau lapaʻau a me ka hoʻomohala ʻana i nā lāʻau lapaʻau ma muli o kona mau waiwai antibiotic. Hana kēia hui ma ke ʻano he poloka kūkulu koʻikoʻi no ka synthesis o nā mea antibacterial i hoʻolālā ʻia e kuhikuhi i nā ʻano bacteria kikoʻī a kāohi i ko lākou ulu ʻana. ʻO kona hoʻonohonoho ʻana i ke ʻano e ʻae ai i nā pilina pololei me nā enzyme bacteria, e hoʻopilikia ana i nā kaʻina hana koʻikoʻi a alakaʻi i nā hopena bactericidal. Eia kekahi, ʻo (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid ke kuleana koʻikoʻi i ka hakakā ʻana i nā maʻi bacteria e hoʻoweliweli nei i ke olakino kanaka. Ma ka hoʻokomo ʻana i kēia hui i loko o nā ʻano antibiotic, makemake nā mea noiʻi e hoʻomohala i nā koho therapeutic hou me ka hoʻonui ʻana i ka pono a me ka hoʻemi ʻana i ke kūʻē. Hoʻopili ke ʻano hana o ka hui i nā paia cell bacteria a i ʻole ka synthesis protein, e hāʻawi ana i kahi ākea ākea o ka hana e kūʻē i nā bacteria Gram-positive a me Gram-negative, me nā ʻano multidrug-resistant. Eia kekahi, ke kālele nei nā hana noiʻi i ka hoʻonui ʻana i nā waiwai pharmacokinetic o (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid e hoʻomaikaʻi i kona bioavailability a me ka hoʻolaha ʻana i loko o ke kino. Pili kēia kaʻina hana hoʻonui i ka ʻimi ʻana i nā ʻano hana hoʻouna lāʻau like ʻole, e like me nā prodrugs, nanoparticles, a i ʻole nā ​​​​​​formulations liposomal, e hoʻonui i ka hiki ke therapeutic o ka hui a hoʻemi i nā hopena ʻaoʻao. I ka hopena, ʻo (6R-trans)-7-amino-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid he waiwai nui ia ma ke kahua o ka mālama ʻana i nā maʻi lele, e hāʻawi ana i nā hopena hoʻohiki no ka hoʻoponopono ʻana i ke kūʻē ʻana o ka bacteria a me ka hoʻomaikaʻi ʻana i nā hopena o ka mea maʻi. ʻO kāna mau hoʻohana like ʻole i ka lāʻau antibiotic e hōʻike ana i kona koʻikoʻi i ka lāʻau lapaʻau hou a hōʻike i kona hiki ke hoʻokele i ka hana hou i ka hoʻomohala ʻana i nā antibiotics hanauna hou.