Candesartana Cilexetila CAS:145040-37-5

ʻO Candesartan cilexetil kahi hua o ka mea ikaika, lōʻihi, a me ka angiotensin II type 1 receptor AT1 antagonist, candesartan.Hoʻopili wikiwiki ʻia ia i ka candesartan i ka wā o ka ʻai ʻana o ka ʻōpū.Ma hope o ka hydrolysis o ka candesartan cilexetil i candesartan i ka wā o ka hoʻopili ʻana o ka ʻōpū, hoʻokūkū koho ʻo candesartan me ka angiotensin II no ka hoʻopaʻa ʻana o ka angiotensin II receptor subtype 1 AT1 i loko o ka ʻiʻo vascular smooth, kaohi ʻana i ka angiotensin II-mediated vasoconstriction a me ka hoʻoulu ʻana i ka vasodilation.Eia kekahi, ʻo ka antagonism o AT1 i loko o ka adrenal gland e kāohi i ka angiotensin II-stimulated aldosterone synthesis a me ka huna ʻana e ka adrenal cortex;Hoʻonui ka sodium a me ka excretion wai, a ma hope o ka emi ʻana o ka nui o ka plasma a me ke kahe koko.