ʻO (S)-tert-Butyl 2-methylaziridine-1-carboxylate CAS:197020-60-3

He kuleana koʻikoʻi ko (S)-tert-Butyl 2-methylaziridine-1-carboxylate ma ke ʻano he waena i ka synthesis o nā hui paʻakikī, bioactive me nā noi lāʻau lapaʻau hiki. ʻO kona hoʻokomo ʻia ʻana i loko o nā ʻōnaehana molekala e hiki ai i nā mea noiʻi ke ʻimi i nā moho lāʻau lapaʻau hou e kuhikuhi ana i nā wahi therapeutic e like me nā mea antitumor, nā mea hoʻopaʻa enzyme, a i ʻole nā ​​​​poloka hale chiral no ka synthesis lāʻau lapaʻau. ʻO ke alo o ka chiral aziridine core e hoʻolauna i ka reactivity kikoʻī a me nā waiwai pharmacophoric, e lilo ia i mea waiwai no ka noiʻi kemika lāʻau lapaʻau. I nā hana ʻike lāʻau lapaʻau, hiki i kēia hui ke lawelawe ma ke ʻano he kumu hoʻomaka no ka hoʻolālā ʻana i nā moho lāʻau lapaʻau hiki, e hoʻohana ana i kona mau hiʻohiʻona kūkulu e hoʻololi i ka hana olaola a me nā waiwai pharmacokinetic. Eia kekahi, hiki i ke ʻano chiral o ka mole ke hoʻohuli i kāna mau pilina me nā pahuhopu olaola, e hoʻopilikia paha i kona mau waiwai pharmacological a hoʻonui i kona pono i ka hoʻomohala ʻana i ka lāʻau. Eia kekahi, ma nā wahi hoʻonaʻauao a me nā ʻoihana, hiki i nā mea noiʻi ke hoʻohana i kēia poloka hale e hoʻomākaukau i nā hale waihona puke o nā derivatives like ʻole no nā haʻawina pilina hana-hana, e hoʻomaʻamaʻa ana i ka ʻike ʻana i nā hui alakaʻi me nā hopena olaola i makemake ʻia. ʻO kona kuleana i ka synthesis kemika e hoʻonui i ka hana ʻana o nā waena lāʻau lapaʻau a me ka hoʻomohala ʻana i nā ʻano hana synthetic hou, e hōʻike ana i kona pono ākea ma waena o nā aʻo ʻepekema. Ma keʻano holoʻokoʻa, he kuleana koʻikoʻi ko (S)-tert-Butyl 2-methylaziridine-1-carboxylate i ka ʻike ʻana i nā lāʻau lapaʻau hou a me ka noiʻi kemika, e hāʻawi ana i kahi kahua no ka hoʻomohala ʻana i nā molekala biologically active like ʻole a me nā mea lapaʻau waena.