Simvastatin CAS:79902-63-9 Mea Hana Mea Hoʻolako

He semi-synthetic ʻo Simvastatin, ʻoi aku ka hydrophobic, analogue o lovastatin. E like me lovastatin, he mea hoʻopaʻa kikoʻī ʻo simvastatin o ka HMG-CoA reductase a hoʻohana ʻia i ka therapeutically e hōʻemi i ka LDL cholesterol. ʻOi aku nei, ua lilo nā statins i mau probes biochemical koʻikoʻi i ka biology cell. Hiki ke hoʻopili ʻia ko lākou komo ʻana i nā hanana he nui i kā lākou ʻano hana mua, akā naʻe, ʻaʻole maopopo loa ke ʻano o ka hana o nā hopena ʻē aʻe. He mea hoʻopaʻa kikoʻī ʻo Simvastatin o ka HMG-CoA reductase, ka enzyme e hoʻololi i ka hoʻololi ʻana o HMG-CoA i mevalonate, kahi hana mua i ka biosynthesis cholesterol. Hoʻohana ʻia ia i ka mālama ʻana i ka hypercholesterolemia, no ka mea e hōʻemi ana i nā pae o nā lipoproteins haʻahaʻa a me nā triglycerides, a hoʻokiʻekiʻe i nā pae lipoprotein kiʻekiʻe.